The gut-brain axis (GBA) is a two-way communication between the central and enteric nervous systems. Recent advances in research have described the importance of the gut microbiota in influencing these interactions. The interaction between the microbiota and the brain appears to be bidirectional, including signaling from the gut microbiota to the brain and from the brain to the gut microbiota.

We are developing at NETRI compartmentalized microfluidic devices, with an enhanced fluidic isolation, and coupled with high-throughput MultiElectrod Arrays (MEAs), in collaboration with Axion BioSystems. These devices allow co-culture of 3 cell types in 3 isolated but connected compartments, such as neurons, intestinal cells and microbiota, to understand their interactions and their functional effects on neurons. 

CAPABILITIES Functional Activity, Co-culture, hiPSC Derived Cell, Readouts
CELL TYPE Dopaminergic Neurons, Vagus nerve, Gut Cells & Microbiota
RESOURCES Publications, Application Note,Posters, Cells DataSheet
(FujiFilm CDI, BrainXell), Chip DataSheet
READINESS LEVEL ③④/ ⑧ Protocol done for Dopaminergic Neurons