Parkinson’s disease (PD) is a neurodegenerative disease that causes involuntary or uncontrollable movements. The most prominent signs and symptoms of PD occur when dopaminergic neurons in the basal ganglia degenerate. MPTP and 6OHDA are 2 neurotoxins involved in the aggregation of alpha-synuclein (α-Syn) peptide and in the degeneration of dopaminergic neurons. Currently, the internalization of these 2 toxins in neurons is still an unknown mechanism as well as their actions on the α-Syn peptide.
We have developed at NETRI compartmentalized microfluidic devices with an enhanced fluidic isolation allowing neurotoxins testing only on somas or axons.
| CAPABILITIES | Co-culture, hiPSC Derived Cell, Readouts |
| CHIP | DuaLink |
| CELL TYPE | Dopaminergic Neurons |
| RESOURCES | Publications, Application Note, Application Protocol, Posters, Cells DataSheet |
| (FujiFilm CDI, BrainXell), Chip DataSheet | |
| RELATED PAPERS | Seidi, A., Kaji, H., Annabi, N., Ostrovidov, S., Ramalingam, M., & Khademhosseini, A. (2011). A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease. Biomicrofluidics, 5(2), 1–14. |
| READINESS LEVEL | ④/ ⑧ Protocol done |
