Parkinson’s disease (PD) is a neurodegenerative disease that causes involuntary or uncontrollable movements. The most prominent signs and symptoms of PD occur when dopaminergic neurons in the basal ganglia degenerate. MPTP and 6OHDA are 2 neurotoxins involved in the aggregation of alpha-synuclein (α-Syn) peptide and in the degeneration of dopaminergic neurons. Currently, the internalization of these 2 toxins in neurons is still an unknown mechanism as well as their actions on the α-Syn peptide.

We have developed at NETRI compartmentalized microfluidic devices with an enhanced fluidic isolation allowing neurotoxins testing only on somas or axons.