ADME corresponds to descriptors quantifying the drug: passage through the intestinal wall (A); movement between compartments (D); mechanisms of metabolism (M); excretion or elimination (E); and transport (T) is sometimes added. Characterization of the properties of absorption, distribution, metabolism, and excretion allows exploration and explanation of how pharmacokinetic processes occur, to provide safety considerations for a new drug upon which risk-based assessments can be made.
To develop a predictive and relevant ADME model, we are developing at NETRI a multi-organ-on-chip microfluidic device that anticipates drug distribution, metabolism and elimination. With its 3 3D-Deposition Chambers and loop, it is possible to co-culture brain, intestine, skin, liver and kidney cells separately while keeping a connection with the loop.
|CAPABILITIES||Barriers, Co-culture & compartmentalization, Readouts|
|CHIP||R&D Duplex Loop|
|CELL TYPE||hiPSCs/primary cells|
|RESOURCES||Publications, Application Note,Posters|
|READINESS LEVEL||② / ⑧ Protocol done for one cell type|