ADME corresponds to descriptors quantifying the drug: passage through the intestinal wall (A); movement between compartments (D); mechanisms of metabolism (M); excretion or elimination (E); and transport (T) is sometimes added. Characterization of the properties of absorption, distribution, metabolism, and excretion allows exploration and explanation of how pharmacokinetic processes occur, to provide safety considerations for a new drug upon which risk-based assessments can be made.
To develop a predictive and relevant ADME model, we are developing at NETRI a multi-organ-on-chip microfluidic device that anticipates drug distribution, metabolism and elimination. With its 3 3D-Deposition Chambers and loop, it is possible to co-culture brain, intestine, skin, liver and kidney cells separately while keeping a connection with the loop.
| CAPABILITIES | Barriers, Co-culture & compartmentalization, Readouts |
| CHIP | R&D Duplex Loop |
| CELL TYPE | hiPSCs/primary cells |
| RESOURCES | Publications, Application Note,Posters |
| READINESS LEVEL | ② / ⑧ Protocol done for one cell type |
