Synaptic transmission is the biological process by which a neuron communicates with a target cell through a synapse. Chemical synaptic transmission involves the release of a neurotransmitter from the pre-synaptic neuron and the binding of that neurotransmitter to specific post-synaptic receptors. Electrical synaptic transmission involves the transfer of electrical signals across gap junctions.

We have developed at NETRI a microfluidic device with an asymmetric architecture that allows the isolation of synapses in one compartment. Coupled with MEA plates, in collaboration with Axion BioSystems, these devices allow the study of electrical synaptic transmission.