Virus & protein transport
Compartmentalized devices allows to fluidically isolate two or more cellular populations, even when connected by microchannels. When using neurons, geometrical constraints due to microchannels allows neurites to grow and create functional compartment with distal neurons, both in a unidirectional or bidirectional way. Thanks to the fluidic isolation between compartments, a virus or protein can be applied to one cell population only and their transport can be monitored on the remote compartment or within the axons themselves.
Gradient & migration
Microchannels geometries can also be adapted to create gradients of secreted molecules or to allow migrating cells to pass from one compartment to the other.