Synaptic compartment

Asymetric architecture of DuaLink Shift microfluidic devices allow the reconstitution of a neural network between two neural populations connected through a fluidically isolated synaptic compartment. Thanks to the asymetry of the connecting microchannels, axons from one population connect to dendrites from the other, with a high probability, only in the middle compartment. The use of multiplexed microchannels offers also the possibility to study subcellular trafficking while altering synapses.

Synapses & electrophysiology

Coupled to MEA, the DuaLink Shift MEA can be used to monitor the electrophysiological impact of a compound when applied in the synaptic chamber only. Alternatively, by seeding cells in the middle compartment when a neural network is matured, interactions between several type of cells and synapses can be monitored.