Synaptic compartment

Asymetric architecture of DuaLink Shift microfluidic devices allow the reconstitution of a neural network between two neural populations connected through a fluidically isolated synaptic compartment. Thanks to the asymetry of the connecting microchannels, axons from one population connect to dendrites from the other, with a high probability, only in the middle compartment. The use of multiplexed microchannels offers also the possibility to study subcellular trafficking while altering synapses.