Licensing Overview.
A license is required for our industrial partners wishing to use NETRI’s proprietary and patented technologies (platforms & digital library) in-house. NETRI’s organs-on-chip represent a major breakthrough in this field to de-risk with confidence and assurance by having safe GO or NO-GO answers your drug development pipeline.
A Unique Solution.
• Initialization of your digital library: CRO Services in our lab to test your compounds / reference compounds
• Technology transfer to your lab: online or onsite training to integrate our organs-on-chip seamlessly into your lab
• Licensing: recurrent purchase of our organs-on-chip for routine use in your lab and fully access to your digital library
Licensing Portfolio.
Food Safety.
• Neurotoxicology
• Small molecules toxicology
• Liver / Kidney toxicology
• Blood Brain Barrier
Pain.
• Neuroinflammation
• IBD
• NSAIDs
• ALS (NMJ)
• Botox-Like
• CIPN
• Traumatic Injuries
• Emetic response
Neurological Troubles.
• Alzheimer’s disease
• Parkinson's disease
• Multiple Sclerosis
• In-vitro diagnosis
• Huntington's disease
Food Safety Program.
All food products or chemical elements ingested directly or indirectly by humans must be tested for potential neurotoxicological effects before being approved by regulatory authorities. The majority of pre-clinical tests were carried out on non-human primates, and since 2020, soaring prices and accessibility have prompted healthcare industries to seek alternative solutions enabling them to assess neurotoxicological effects on a massive scale.
By using neurons as a sensor approach, NETRI's technologies make it possible to test directly on neurons and objectify the potential toxicological effects of food products or chemical elements, enabling industries to obtain a rapid and reliable predictive alternative in the development process, from the discovery phase through to the preclinical and clinical phases..
• Neurotoxicology
• Small molecules toxicology
• Liver / Kidney toxicology
• Blood Brain Barrier
Pain Program.
Whether it's pain induced by chemotherapy or vaccine injections, or vomiting induced by ingested drugs, healthcare industries are unable to objectively measure these side effects with current conventional methods, resulting in 80% of clinical phases failing.
By using neurons as a sensor approach, NETRI's technologies can objectify the adverse effects caused by drugs, therapies or vaccines, enabling healthcare industries to obtain predictive clinical responses quickly and reliably from drug dsicovery, to preclinical or clinical phase.
• Neuroinflammation
• IBD
• NSAIDs
• ALS (NMJ)
• Botox-Like
• CIPN
• Traumatic Injuries
• Emetic response
Dermatology Program.
The dermo-cosmetics industry can no longer use animal models to develop new ingredients. Alternative solutions, such as NETRI's organs-on-chip, enable them to meet this challenge.
What's more, by using neurons as a sensor approach, NETRI's technologies can objectivize sensations of well-being, pain, irritation and scratching in indications such as eczema, atopic dermatitis or pruritus, enabling industries to get predictive answers quickly and reliably into the development process.
• Diabetes
• Itching
• Burn victim
• Purit
• Demartite atopic
Neurological Troubles Program.
Of the 150,000 patients suspected of having a neurological disorder in France, only 30,000 are diagnosed with Alzheimer's disease during their lifetime. There are no diagnostic tools for Alzheimer's disease or dementia, which are diagnosed post-mortem.
By using neurons as a sensor approach of Central Nervous System (CNS) informationcreate a digital signature of Alzheimer's disease by applying cerebrospinal fluid from a lumbar puncture. This makes it possible to create a digital library of these neurological disorders and offer a systematic diagnostic service.
• Alzheimer’s disease
• Parkinson's disease
• Multiple Sclerosis
• In-vitro diagnosis
• Huntington's disease
Related Resources.
Parvatam, S., Pamies, D., Pistollato, F., Beken, S., Mariappan, I., Roth, A., … & Coecke, S. (2023). Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2023.11.008
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568. https://doi.org/10.3390/ ijms241310568
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021. https://doi.org/10.29328/journal.apps.1001039
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301. https://doi.org/10.3390/pharmaceutics14112301
Maisonneuve, B. G. C., Libralesso, L., Miny, L., Batut, A., Rontard, J., Gleyzes, M., … & Honegger, T. (2022). Deposition chamber technology as building blocks for a standardized brain-on-chip framework. Microsystems & Nanoengineering, 8(1), 86. https://doi.org/10.1038/s41378-022-00406-x
Miny, L., Maisonneuve, B. G., Quadrio, I., & Honegger, T. (2022). Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Frontiers in Bioengineering and Biotechnology, 10, 919646. https://doi.org/10.3389/fbioe.2022.919646
Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67. https://doi.org/10.3390/cosmetics9040067
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748, https://doi.org/10.3791/62748
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03. https://doi.org/10.1101/2021.03.05.434080
Honegger, T., Scott, M. A., Yanik, M. F., & Voldman, J. (2013). Electrokinetic confinement of axonal growth for dynamically configurable neural networks. Lab on a Chip, 13(4), 589-598. https://doi.org/10.1039/C2LC41000A
Honegger, T., Thielen, M. I., Feizi, S., Sanjana, N. E., & Voldman, J. (2016). Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks. Scientific reports, 6(1), 28384. https://doi.org/10.1038/srep28384
Maisonneuve, B. G. C., Batut, A., Varela, C., Vieira, J., Gleyzes, M., Rontard, J., … & Honegger, T. (2021). Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system. bioRxiv, 2021-03. https://doi.org/10.1101/2021.03.23.436675
Fantuzzo, J., Robles, D., Mirabella, V., Hart, R., Pang, Z., Zahn, J. (2020). Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab on a Chip, 2020-02. https://doi.org/10.1039/c9lc01179j
[2024] Characterizing sensory neurons as universal bio-digital sensors to explore PNS applications
[2024] Traumatic Nerve Injury Platform
[2023] Surface tension-based cell seeding in NETRI microfluidic devices
[2022] Synaptic transmission investigation using asymmetric shape microfluidic device DuaLink Shift
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures
[2022] Innovative microfluidic device for in vitro 3D cell culture
Neurosciences 2024
Development of a Brain Organoid-on-Chip Platform for Neurotoxicity Testing
Digital Signature Library: using neurons as universal bio-digital sensors
EUROoCS 2024
Translational brain-on-a-chip models for Alzheimer’s disease drug discovery
Compartimentalized MEA Pain(s)-on-chip platform
MPS World Summit 2024
Compartimentalized MEA Pain(s)-on-chip platform
Translational brain-on-a-chip models for Alzheimer’s disease drug discovery
AD/PD 2024
Advancing Alzheimer’s disease models for target validation and drug discovery
World of organoids 2024
Prediction algorithm for neurotoxicity evaluation based on brain organoid-on-chip
SfN 2023
Towards new relevant Alzheimer’s disease models for target validation and drug testing
Translational platforms of injury & pain-on-chip
Automated organs-on-chip platform to reduce intra-laboratory cell culture variability
MPS World Summit 2023
Automated Organs-on-chip platform to reduce intra-laboratory cell culture variability
Translational model of nerve injury-on-chip
PNS 2023
Translational model of nerve injury-on-chip
NeuroFrance 2023
Translational model of nerve injury-on-chip
SfN 2022
NeoBento High Throughput Format
Pain-on-Chip – Motor nerve injury
FENS 2022
An Organ on chip platform to evaluate neuro immune signal transmission using human cells
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
EUROoCS 2022
Deposition chamber technology as building blocks for a standardized brain on chip framework
Development of an innervated skin-on-a-chip
Human Brain-Organoids-on-ChipAdvanced microfluidic device for reproducible organoids culture
Organs-on-Chip high throughput platform for pharmaceutical screening
The DuaLink chips Improved fluidic isolation in microfluidic devices designed for neurons culture
MPS World Summit 2022
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Human Brain-Organoids-on-Chip Advanced microfluidic device for reproducible organoids culture
Organs-on-Chip high throughput platform for pharmaceutical screening
Microphysiological Systems Workshop
Human Brain-Organoids-on-Chip: Advanced microfluidic device for reproducible organoids culture
SLAS International 2022
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
MPS World Summit 2021
Deposition chamber technology as building blocks for a standardized brain-on-chip framework
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Neurosciences 2021
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
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