Alzheimer.
Description
Capabilities
Chip
Cell Types
Resources
Description
Alzheimer’s (AD) is a progressive neurological disorder that affects the brain leading to cognitive decline and memory loss. It is the most common dementia accounting for 60-80% of cases. In AD, abnormal aggregation of peptides (Aβ and Tau) form oligomers and fibrils, leading to neuronal degeneration, synaptic dysfunction and neuronal death. There is currently no cure for Alzheimer’s disease.
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of several neural cell types, making it the perfect platform to test and/or screen drugs or therapeutics.
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of several neural cell types, making it the perfect platform to test and/or screen drugs or therapeutics.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Axonal transport
• Functional activity
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.
Chip
• DuaLink MEA: specific architecture with a custom Axion Biosystems MEA Layer for 2 isolated cultures connected via axons & their functional activity recording.
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.
Cell Types
• Co-culture of hiPSC-derived glutamatergic neurons & GABAergic neurons
• Co-culture of rodent cortical neurons & hippocampal neurons
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Resources
Parkinson.
Description
Capabilities
Chip
Cell Types
Resources
Description
Parkinson’s disease (PD) is a progressive neurological disorder that affects movement. It shows motor and non-motor symptoms, including depression, anxiety, sleep disturbances, and cognitive impairment. It is caused by the dysfunction and the death of dopaminergic neurons, leading to a reduction of dopamine in the brain. One characteristics of PD is the abnormal accumulation of aggregated peptide called alpha-synuclein, inducing neuronal injury. There is no cure for Parkinson’s disease.
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of several neural cell types, making it the perfect platform to test and/or screen drugs or therapeutics.
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of several neural cell types, making it the perfect platform to test and/or screen drugs or therapeutics.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Axonal transport
• Synaptic isolation
• Functional activity
.
.
Chip
• DuaLink Shift MEA: specific asymmetric architecture with a custom Axion Biosystems MEA Layer for synapses isolation & their functional activity recording.
.
.
Cell Types
• Co-culture of hiPSC-derived glutamatergic neurons & GABAergic neurons
• Co-culture of rodent cortical neurons & hippocampal neurons
.
.
Resources
Amyotrophic Lateral Sclerosis.
Description
Capabilities
Chip
Cell Types
Resources
Description
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s or Charcot’s disease is a progressive neurodegenerative disorder that affects the nerve cells responsible for controlling voluntary muscle movement. ALS damages the motor neurons in the brain and spinal cord, which leads to muscle weakness and wasting. Inclusions of modified TDP-43 have been identified in 97% of ALS cases. The cause of ALS is not fully understood, but genetics and environmental factors may play a role. There is no cure for ALS
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of neural cells and muscle cells, making it the perfect platform to test and/or screen drugs or therapeutics.
At NETRI, we have developed microfluidic devices enabling the compartmentalized co-culture of neural cells and muscle cells, making it the perfect platform to test and/or screen drugs or therapeutics.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Axonal transport
• Functional activity
.
• hiPSC culture
• Axonal transport
• Functional activity
.
Chip
• DuaLink MEA: specific architecture with a custom Axion Biosystems MEA Layer for 2 isolated cultures connected via axons & their functional activity recording.
.
.
Cell Types
• Co-culture of hiPSC-derived motor neurons & muscle cells (myocytes)
.
.
Resources