Pain & Injury in vitro Models.
Combining the right microfluidic architecture with the right cell type, compound and readouts, discover our in-vitro models with their own TRL.
Chemotherapy Induced Peripheral Neuropathic.
Description
Capabilities
Chip
Cell Types
Resources
Description
More than 80% of patients will experience peripheral neuropathy during their chemotherapy treatment. For 20 to 30% the symptoms will become chronic, mostly due to permanent nerve damage. Current pain relief options are not efficient on neuropathic pain or pose the risk of opiod addiction.
We have developed at NETRI a specific microfluidic devices architectures to isolate neurites and somas, into which we can mimic the insult from neoplastic agents onto sensory neurons, to help solve this unmet therapeutic need.
We have developed at NETRI a specific microfluidic devices architectures to isolate neurites and somas, into which we can mimic the insult from neoplastic agents onto sensory neurons, to help solve this unmet therapeutic need.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
.
.
Chip
• DuaLink: specific compartmentalized architecture with microchannels tunnels for enhanced fluidic isolation & 2 isolated cultures connected via axons
.
.
Cell Types
• hiPSC-derived sensory neurons
.
.
Resources
Motor Nerve Injury.
Description
Capabilities
Chip
Cell Types
Resources
Description
Traumatic nerve injury affects millions of people of all ages around the world and can potentially lead to irreversible damages without any immediate therapeutics available. There is a significant demand for physiologically relevant in vitro models of nerve injury. The major modeling challenge is to accurately perform the injury only on the neurites without affecting cell viability and to apply the pre-clinical stage compounds on compartment of interest only.
We have developed at NETRI microfluidic devices with a triangular architecture to isolate neurites and somas and to monitor neurite growth in time.
We have developed at NETRI microfluidic devices with a triangular architecture to isolate neurites and somas and to monitor neurite growth in time.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Growth kinetics & axotomy
.
.
Chip
• DuaLink Delta Ultra : specific triangular architecture with microchannels of different length for growth kinetics and enhanced axonal projection
.
.
Cell Types
• hiPSC-derived motor neurons
.
.
Resources
Sensory Nerve Injury.
Description
Capabilities
Chip
Cell Types
Resources
Description
Traumatic nerve injury will affect both motor and sensory neurons. While damage to the motor neurons will cause a loss of function, injury to the sensory fibers will generate abnormal pain responses.
We created a standardized method to create a reproducible sensory nerve injury on axons only.
We have developed at NETRI microfluidic devices with a triangular architecture to isolate neurites and somas and to monitor neurite growth in time.
We created a standardized method to create a reproducible sensory nerve injury on axons only.
We have developed at NETRI microfluidic devices with a triangular architecture to isolate neurites and somas and to monitor neurite growth in time.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Growth kinetics & axotomy
.
.
Chip
• DuaLink Delta Ultra : specific triangular architecture with microchannels of different length for growth kinetics and enhanced axonal projection
.
.
Cell Types
• hiPSC-derived sensory neurons from Axol Bioscience
.
.
Resources
Peripheral neuropathic pain.
Description
Capabilities
Chip
Cell Types
Resources
Description
Peripheral neuropathic pain is cause by sensory neurons alterations. Damages to the sensory neurons can be due to chemical agents such as anti-cancer drugs or metabolic changes as in diabetis.
We have developed at NETRI a specific microfluidic devices architectures to isolate neurites and somas, study mode of actions and enhanced axonal projection rate.
.
We have developed at NETRI a specific microfluidic devices architectures to isolate neurites and somas, study mode of actions and enhanced axonal projection rate.
.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
.
.
.
Chip
• DuaLink Ultra: specific 3-compartments microfluidic devices architectures to isolate neurites & somas and enhanced axonal projection rate.
.
.
.
Cell Types
• hiPSC-derived sensory neurons from Axol Bioscience
.
.
.
Resources
Nociceptive pain.
Description
Capabilities
Chip
Cell Types
Resources
Description
Pain is caused by tissue damage. Sensory nerves detect tissue damage via specific receptors (nociceptors) and transmit information about the damage along the spinal cord to the brain for interpretation. Activation of nociceptors is at the basis of nociceptive pain and allodynia (activation by stimuli that usually does not provoke pain). In those cases, pain occurs with a normally functioning nervous system.
We have developed, in collaboration with Axion Biosystems, a MEA-capable high-throughput compartmentalized microfluidic device to record the neurons functional activity.
We have developed, in collaboration with Axion Biosystems, a MEA-capable high-throughput compartmentalized microfluidic device to record the neurons functional activity.
Capabilities
• Co-culture & compartmentalization
• hiPSC culture
• Functional activity
.
.
Chip
• DuaLink MEA: specific architecture with a custom Axion Biosystems MEA Layer for 2 isolated cultures connected via axons & their functional activity recording
.
.
Cell Types
• hiPSC-derived sensory neurons from Axol Bioscience
.
.
Resources