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Compartmentalized microenvironnements

The microchannels technology allows a fluidic isolation between the compartments of the NeuroFluidics™ line which allows the creation of compartmentalized microenvironments.

  • Application of different culture media
  • Ensures appropriate differentiation and maintenance of cell cultures
  • Co-culture of neurons, such as in Huntington disease
  • Co-culture of neurons and non-neural cells, such as in gut brain axis
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Neurites isolation

Due to their micrometric measurement the microchannels technology allow the isolation of neurites. Only neurites can grow within the microchannels, leaving the cell bodies within the compartements themselves.

  • Minimal leakage
  • Testing compounds only on neurites or somas
  • Physiological cellular connexion between neurites and non-neural cells, such as in innervated skin
  • Modelling the mode of action of proteins or peptides, such as in in Alzheimer's disease, Amyotrophic Lateral Sclerosis or Parkinson's disease
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Fluidic isolation improvement

In our NeuroFluidics™ line, either with microchannels tunnels or grooves, the fluid leakage is significantly reduced, compared to the two-channel device, with a maximal leakage value divided by 2 to 3.

  • Reproducibility in statistical discrimination between test conditions
  • Reproducibility of readouts
  • Intra and inter individual reproducibility
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