Alzheimer’s (AD) is a type of dementia that affects memory, thinking and behavior. AD has no cure and is at the forefront of biomedical research today. AD is cause by hippocampal and cortical neurons degeneration. Their degeneration result in part from abnormal aggregation of Aβ42, key peptide involved in AD. Currently, scientists still do not know what causes the aggregation of Aβ42 and its mechanism on hippocampal and cortical neurons.
We have developed at NETRI compartmentalized microfluidic device architectures, with an enhanced fluidic isolation, to understand the causes of Aβ42 aggregation and its mode of action in AD.