Alzheimer’s (AD) is a type of dementia that affects memory, thinking and behavior. AD has no cure and is at the forefront of biomedical research today. AD is cause by hippocampal and cortical neurons degeneration. Their degeneration result in part from hyperphosphorylation of Tau, key peptide involved in AD. Currently, scientists still do not know what causes the hyperphosphorylation of Tau and its mechanism on hippocampal and cortical neurons.
We have developed at NETRI microfluidic devices with a triangular architecture to quantify the degeneration of neurons depending on an abnormal hyperphoporylated form of Tau.