Parkinson’s disease (PD) is a neurodegenerative disease that causes involuntary or uncontrollable movements. The most prominent signs and symptoms of PD occur when dopaminergic neurons in the basal ganglia degenerate. Due to its complex pathology, there is currently no disease model that replicates all aspects of human PD.
To model human PD, we are developing at NETRI a microfluidic device with a complex architecture that reproduces in proportion the basal ganglia loop. With its 5 3D-Deposition Chambers of different sizes and identically connected to the different parts of the basal ganglia loop, our PentaLink allows to recreate the basal ganglia loop at the micron scale.
|CAPABILITIES||Co-culture, hiPSC Derived Cell, Readouts|
|CELL TYPE||Dopaminergic Neurons|
|RESOURCES||Publications, Application Note, Application Protocol, Posters, Cells DataSheet|
|(FujiFilm CDI, BrainXell), Chip DataSheet|
|RELATED PAPERS||Seidi, A., Kaji, H., Annabi, N., Ostrovidov, S., Ramalingam, M., & Khademhosseini, A. (2011). A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease. Biomicrofluidics, 5(2), 1–14.|
|READINESS LEVEL||④/ ⑧ Protocol done|