Organs-on-chip Kits Overview.
De-risk with confidence and assurance by having safe GO or NO-GO answers in your drug development pipeline.
Organs-on-chip Kit Portfolio.
NeuroFluidics™ Devices.
Generic platforms.
• High-throughput & interoperable devices
• Pump-free devices
Fully compatible with auromated lab equipment
NeuroFluidics™ Kits.
Generic cells & platforms.
• Right architecture with right cells and readouts
• Recreate healthy or disease models
NeuroFluidics™ Digital.
Generic software.
• Translate physiological behaviors of central and peripheral nervous system
• Utility software
Our Program Areas.
Food Safety.
• Neurotoxicology
• Small molecules toxicology
• Liver / Kidney toxicology
• Blood Brain Barrier
Pain.
• Neuroinflammation
• IBD
• NSAIDs
• ALS (NMJ)
• Botox-Like
• CIPN
• Traumatic Injuries
• Emetic response
Neurological Troubles.
• Alzheimer’s disease
• Parkinson's disease
• Multiple Sclerosis
• In-vitro diagnosis
• Huntington's disease
Related Resources.
Parvatam, S., Pamies, D., Pistollato, F., Beken, S., Mariappan, I., Roth, A., … & Coecke, S. (2023). Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2023.11.008
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568. https://doi.org/10.3390/ ijms241310568
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021. https://doi.org/10.29328/journal.apps.1001039
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301. https://doi.org/10.3390/pharmaceutics14112301
Maisonneuve, B. G. C., Libralesso, L., Miny, L., Batut, A., Rontard, J., Gleyzes, M., … & Honegger, T. (2022). Deposition chamber technology as building blocks for a standardized brain-on-chip framework. Microsystems & Nanoengineering, 8(1), 86. https://doi.org/10.1038/s41378-022-00406-x
Miny, L., Maisonneuve, B. G., Quadrio, I., & Honegger, T. (2022). Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Frontiers in Bioengineering and Biotechnology, 10, 919646. https://doi.org/10.3389/fbioe.2022.919646
Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67. https://doi.org/10.3390/cosmetics9040067
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748, https://doi.org/10.3791/62748
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03. https://doi.org/10.1101/2021.03.05.434080
Honegger, T., Scott, M. A., Yanik, M. F., & Voldman, J. (2013). Electrokinetic confinement of axonal growth for dynamically configurable neural networks. Lab on a Chip, 13(4), 589-598. https://doi.org/10.1039/C2LC41000A
Honegger, T., Thielen, M. I., Feizi, S., Sanjana, N. E., & Voldman, J. (2016). Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks. Scientific reports, 6(1), 28384. https://doi.org/10.1038/srep28384
Maisonneuve, B. G. C., Batut, A., Varela, C., Vieira, J., Gleyzes, M., Rontard, J., … & Honegger, T. (2021). Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system. bioRxiv, 2021-03. https://doi.org/10.1101/2021.03.23.436675
Fantuzzo, J., Robles, D., Mirabella, V., Hart, R., Pang, Z., Zahn, J. (2020). Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab on a Chip, 2020-02. https://doi.org/10.1039/c9lc01179j
[2024] Characterizing sensory neurons as universal bio-digital sensors to explore PNS applications
[2024] Traumatic Nerve Injury Platform
[2023] Surface tension-based cell seeding in NETRI microfluidic devices
[2022] Synaptic transmission investigation using asymmetric shape microfluidic device DuaLink Shift
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures
[2022] Innovative microfluidic device for in vitro 3D cell culture
Neurosciences 2024
Development of a Brain Organoid-on-Chip Platform for Neurotoxicity Testing
Digital Signature Library: using neurons as universal bio-digital sensors
EUROoCS 2024
Translational brain-on-a-chip models for Alzheimer’s disease drug discovery
Compartimentalized MEA Pain(s)-on-chip platform
MPS World Summit 2024
Compartimentalized MEA Pain(s)-on-chip platform
Translational brain-on-a-chip models for Alzheimer’s disease drug discovery
AD/PD 2024
Advancing Alzheimer’s disease models for target validation and drug discovery
World of organoids 2024
Prediction algorithm for neurotoxicity evaluation based on brain organoid-on-chip
SfN 2023
Towards new relevant Alzheimer’s disease models for target validation and drug testing
Translational platforms of injury & pain-on-chip
Automated organs-on-chip platform to reduce intra-laboratory cell culture variability
MPS World Summit 2023
Automated Organs-on-chip platform to reduce intra-laboratory cell culture variability
Translational model of nerve injury-on-chip
PNS 2023
Translational model of nerve injury-on-chip
NeuroFrance 2023
Translational model of nerve injury-on-chip
SfN 2022
NeoBento High Throughput Format
Pain-on-Chip – Motor nerve injury
FENS 2022
An Organ on chip platform to evaluate neuro immune signal transmission using human cells
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
EUROoCS 2022
Deposition chamber technology as building blocks for a standardized brain on chip framework
Development of an innervated skin-on-a-chip
Human Brain-Organoids-on-ChipAdvanced microfluidic device for reproducible organoids culture
Organs-on-Chip high throughput platform for pharmaceutical screening
The DuaLink chips Improved fluidic isolation in microfluidic devices designed for neurons culture
MPS World Summit 2022
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Human Brain-Organoids-on-Chip Advanced microfluidic device for reproducible organoids culture
Organs-on-Chip high throughput platform for pharmaceutical screening
Microphysiological Systems Workshop
Human Brain-Organoids-on-Chip: Advanced microfluidic device for reproducible organoids culture
SLAS International 2022
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
MPS World Summit 2021
Deposition chamber technology as building blocks for a standardized brain-on-chip framework
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Neurosciences 2021
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
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