DuaLink MEA
For 2 co-cultures, enhanced fluidic isolation & functional activity
Explore
NeuroFluidics™ MEA Line.
3 Products with 3 architectures.
Our NeuroFluidics™ MEA line achieves the fusion of the electrophysiology and microfluidics. In collaboration with
Axion Biosystems we have developed MEA-capable high-throughput compartmentalized microfluidic devices.
Contact us to find out how this disruptive platform can boost your preclinical research.
Pre-orders now open.
DuaLink MEA.
Specially designed for 2 isolated cultures connected via axons & functional activity recording.
With the DuaLink MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate physiologicaly relevant 2 compartments of cell populations & monitor their functional activity :
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 2 for cell culture & 1 for fluidic isolation
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Cell type electrophysology activity isolation per compartment
• Remote stimulation (compound or electrical)
.
With the DuaLink MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate physiologicaly relevant 2 compartments of cell populations & monitor their functional activity :
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 2 for cell culture & 1 for fluidic isolation
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Cell type electrophysology activity isolation per compartment
• Remote stimulation (compound or electrical)
.
All our chips are in the NeoBento format (standard 96-well SBS plate format) and thus offer a variety of handling readouts for your different needs.
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
DuaLink MEA is specially designed to co-culture 2 cell types in channel 1 and 3, and enable the recording of specific neuronal activities in each and accross channels.
In-vitro models
• Innervated skin 2D
• Sensitive skin
Indications
• Neurological Troubles (AD, PD, ALS, MS)
• Skin nociception
Field
• Toxicology
• Virology
• Neuroinflammation
• Itch
• Ageing
Capabilities
• Axonal transport
• Co-culture & compartmentalization
• Functional activity
In-vitro models
• Innervated skin 2D
• Sensitive skin
Indications
• Neurological Troubles (AD, PD, ALS, MS)
• Skin nociception
Field
• Toxicology
• Virology
• Neuroinflammation
• Itch
• Ageing
Capabilities
• Axonal transport
• Co-culture & compartmentalization
• Functional activity
Our aim is to translate physiological behaviors by integrating our technologies within one chip.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
Publications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
DuaLink Shift MEA.
Specially designed for synaptic isolation & functional activity recording.
With the DuaLink™ Shift MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate a physiological synaptic compartmentalization & monitor their functional activity :
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 2 for cell culture & 1 for synaptic isolation
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Asymmetrical shape with microchannels of different length
• Orientation of the network by preferentially allowing axons to develop from channel 3 to channel 1
• Synapses electrophysology activity isolation per compartment
.
With the DuaLink™ Shift MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate a physiological synaptic compartmentalization & monitor their functional activity :
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 2 for cell culture & 1 for synaptic isolation
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Asymmetrical shape with microchannels of different length
• Orientation of the network by preferentially allowing axons to develop from channel 3 to channel 1
• Synapses electrophysology activity isolation per compartment
.
All our chips are in the NeoBento format (standard 96-well SBS plate format) and thus offer a variety of handling readouts for your different needs.
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
DuaLink Shift MEA is specially designed to isolate synaptic connections in channel 2, and enable the recording of specific neuronal activities in each and accross channels.
Indications
• Huntington Disease
• Alzheimer Disease – Glutamate
• Parkinson Disease – αsyn
Field
• Neuroinflammation
• Neuro-immunology
• Synaptic Transmission
Capabilities
• Functional activity
• Synaptic isolation
• Co-culture & compartmentalization
• Axonal transport
.
Indications
• Huntington Disease
• Alzheimer Disease – Glutamate
• Parkinson Disease – αsyn
Field
• Neuroinflammation
• Neuro-immunology
• Synaptic Transmission
Capabilities
• Functional activity
• Synaptic isolation
• Co-culture & compartmentalization
• Axonal transport
.
Our aim is to translate physiological behaviors by integrating our technologies within one chip.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
Publications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
TriaLink MEA.
Specially designed for 3 isolated cultures connected via axons & functional activity recording.
With the TriaLink™ Shift MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate a to recreate physiologicaly relevant 3 compartments of cell populations & monitor their functional activity:
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 3 for cell culture
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Cell type electrophysology activity isolation per compartment
• Remote stimulation (compound or electrical)
.
With the TriaLink™ Shift MEA microfluidic chip, the microchannels, NeoBento™ and electrophysiology technologies are combined in a single microfluidic chip, to recreate a to recreate physiologicaly relevant 3 compartments of cell populations & monitor their functional activity:
• 3 compartments integrated on a custom Axion Biosystems MEA layer: 3 for cell culture
• 16 microfluidic chips per NeoBento™ MEA Pro with 672 electrodes
• 8 microfluidic chips per NeoBento™ MEA Edge with 336 electrodes
• Cell type electrophysology activity isolation per compartment
• Remote stimulation (compound or electrical)
.
All our chips are in the NeoBento format (standard 96-well SBS plate format) and thus offer a variety of handling readouts for your different needs.
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
Electrophysiology (Using AxIS and NETRI’s Uplink utility software)
• Axion MEA metrics (per channel / µchannel)
• Axion MEA Network Metrics (per channel)
• Individual Axion Electrode Metrics
• Compartimentalized Rasterplots
Imaging
• Immunofluorescence
• Calcium Imaging
• Live staining
• Live Dead Assays
Biochimic analysis
• Lysis cells analysis
• Supernatant analysis
• ELISA
• Liquid chromatography
• Mass Spectoscopy
TriaLink MEA is specially designed to co-culture 3 cell types in channel 1, 2 and 3, and enable the recording of specific neuronal activities in each and accross channels.
Indications
• Multiple sclerosis
• Cerebral tumors
Field
• Neuroinflammation
• Gu-Brain-Axis
Capabilities
• Functional activity
• Co-culture & compartmentalization
• Axonal transport
.
Indications
• Multiple sclerosis
• Cerebral tumors
Field
• Neuroinflammation
• Gu-Brain-Axis
Capabilities
• Functional activity
• Co-culture & compartmentalization
• Axonal transport
.
Our aim is to translate physiological behaviors by integrating our technologies within one chip.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
• Electrophysiology: Combining our advanced organs-on-chip devices with Axion Biosystems Maestro MEA benchtop systems allows users to record and analyze each compartmentalized cell population independently, allowing them to better understand the relationships and effects at play.
• Microchannel tunnels: Due to their micrometric measurements, only cell extensions can grow within the microchannels, leaving the cell bodies within the compartments themselves.
• NeoBento HT Format: The NeoBento is our versatile container which is in the standard 96-well microplate format, compatible with standard liquid handling and imaging equipment, and does not require expensive equipment.
.
Publications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks
Electrokinetic confinement of axonal growth for dynamically configurable neural networks
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks
Microfluidic Devices Protocols
NeuroFluidics™ – DuaLink - DuaLink MEA
Cells Types Protocols
Sensory Neurons – Axol Bioscience
Application Notes
Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
Posters
Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications