A breakthrough integration

The coupling of organ-on-chip compartmentalization with electrophysiological recording represents a step change in the way one can isolate and analyze the network relationships of different neuron populations, as well as the targeted influence of drug compounds on specific somas, neurites or even non-neuron cells like gut or muscle.

What are MultiElectrode Arrays (MEAs)?

MEA is a technology used to detect electrophysiological signals. Continuous recordings provide data to investigate a compound’s impact on functional activity and network dynamics. NETRI and Axion BioSystems (Maestro Pro & Edge), a leading life sciences company, have collaboratively developed compartmentalized microfluidic devices coupled with high-throughput (HT) compatible MEAs.

What are the benefits?

  • Functional synapses recording
  • Continuous recordings of functional activity and network dynamics
  • Functional activity of the entire network
  • Study cross-functional influence of connected but compartmentalized cell populations
  • Establish relevant electrophysiological biomarkers
  • Create earlier and more relevant models to accelerate neuroscience-related drug screening and global discovery

Organs-on-chip & functional activity recording

  • Noninvasively measure the electrical activity of neural cells in relevant human in vitro models and accelerate therapeutic discovery
  • Evaluate electrophysiological connectivity between neurons and other cell populations
  • Use algorithms to extract most of the functional markers of the network (connectivity map between chambers, connection weights, small world of the network)
  • Characterize the recovery state of a damaged circuit