IMMUNOLOGY PROGRAM.
INFLAMMATORY.
Inflammation & Neuronal Function.
Inflammation plays a central role in the regulation of neuronal signalling. Cytokines and immune mediators can disrupt neural communication, shaping pain pathways and complicating the development of effective therapies. NETRI’s organ-on-chip platforms recreate human neuro-immune interactions in vitro. By modeling the influence of immune cells (such as macrophages, etc) on neuronal excitability, our systems provide predictive data that accelerate discovery and de-risk clinical pipelines.
• Assessment of inflammatory-mediated neuronal function.
• Investigating how cytokines and immune mediators modulate neural signaling.
• Evaluation of specific immune cell–neuron interactions.
• Systemic inflammation and immune-related disorders.
OTHER POSSIBILITIES.
Next Applications & Models.
NETRI's patented technologies make it possible to innervate any organ, using electrophysiological recordings as a unique readout.
• Modeling neuro-immune crosstalk in chronic inflammation (e.g., multiple sclerosis, neurodegeneration, or pain sensitization).
• In vitro investigation of intestinal inflammation, as IBD models (gut–immune–neuron interactions in Crohn’s disease and ulcerative colitis).
• Immunotoxicity testing in humanized systems (screening the effects of drugs, biologics, or environmental compounds on immune–neuronal balance).
• Discovery of therapeutic targets in immune-driven diseases (leveraging humanized organ-on-chip platforms to identify and validate intervention points).
THE WAY WE WORK.
Out-Licensing.
• Co-development to set up new model & digital library.
• Technology transfert to integrate our technologies in your routine drug development.
• Out-licensing to feed your digital library with new signatures.
Organs-on-chip devices.
• Ready-to-use organs on chip devices.
• 2D and 3D cell culture.
• Innervation & vascularization.
• Classic readouts (sequencing, dosing, imaging...).
• Electrophysiology readouts (MEA).
