ONCOLOGY
Description.
Create a high throughput microscope-free platform to evaluate neurotoxicity as Drug Induced Peripheral Neuropathies (DIPN) for oncology drug development.
Readouts.
• MEA recordings.
• Digital Signatures.
• Imaging.
Advantages.
• Direct recording of neuronal response to compound pain challenge.
• Capacity to discriminate inflammatory, taxanes, platinum salts, vinca alcaloids, ADC.
Description.
Create a high throughput microscope-free platform to evaluate emetic response for oncology drug development and evaluate potential drug candidate combination to lower drug induced GI toxicity.
Readouts.
• MEA recordings.
• Digital Signatures.
• Imaging.
Advantages.
• Direct recording of neural-based emetic response.
• 5HT3 receptor expressed.
• Direct or indirect coupling with gut ephithelium.
POTENTIAL APPLICATIONS.
• Liver Toxicity: co-culture of hiPSC-derived sensory neurons and liver organoids to create an innervated skin NaaS platform.
• Cardiac Toxicity: co-culture of hiPSC-derived sensory neurons and hiPSC-derived cardiac muscle to create an innervated cardiac NaaS platform.
• Brain Toxicity: co-culture of hiPSC-derived sensory neurons and brain organoids to create an neurotoxicity NaaS platform.
• Glioblastoma Drug Efficacy: tri-culture of hiPSC-derived sensory neurons, primary endothelial cells and glioblastoma spheroids to create an innervated & vascularized glioblastoma NaaS platform.
• Drug Efficacy: co-culture of hiPSC-derived sensory neurons and tumoroids to create an innervated tumoroid NaaS platform.
Initialization.
Creation of NaaS biology platform and NaaS Model for a target application.
• In Your Lab: Develop your NaaS Model on your own terms.
• At NETRI: Let NETRI Develop your NaaS Model.
Upscaling.
Build up of Digital NaaS model through Training Library of 100s of reference compounds.
• Pre-Licensing: Test your molecules using your NaaS Model.
Screening & Drug Design.
Transfer of methodology, devices and predictive model capabilities to client.
• Licensing: Screen your molecules using an existing NaaS Model.
Regulatory Approval.
Extension of approved NaaS Model to multiple clients. Larger deals with CROs to handle volumes.
• Licensing & milestones.
