RESOURCES HUB.
150+ resources with our organs-on-chip and digital library technologies.
Bessy, T.; Martinez, A.; Baquerre, C.; Grégoire, C. ; Batut, A.; Berthelin, A.; Dubuisson, L.;Teluob, S.; Azéma, A.; Roussel Berlier, L.; Lelièvre, D.; and Guichard, A. (2026). An in vitro organ-on-chip model for studying neuron–keratinocyte interactions in sensory response through electrophysiology. Lab on a Chip. https://doi.org/10.1039/D5LC00867K
- Bessy, T.; Lambert, T.; Dubuisson, L.; Batut, A.; Azema, A.; Baquerre, C.; Ponomarenko, A.; Roux, S.; Ftaich, N. and Honegger, T. (2025). The NaaS Methodology applied to modeling chemotherapy-induced peripheral neuropathy with human hiPSC neurons. Under review. https://doi.org/10.1101/2025.09.25.678500
- Miny, L.; Rontard, J. ; Allouche, A.; Violle, N. ; Dubuisson, L.; Batut, A. ; Ponomarenko, A.; Talbi, R.; Gautier, H.; Maisonneuve, B.; Roux, S.; Larramendy, F.; Honegger, T. and Quadrio, I. (2025). Functional discrimination of CSF from Alzheimer's patients in a brain on chip platform. https://doi.org/10.1038/s41598-025-97186-x
Castiglione, H. ; Madrange, L. ; Baquerre, C. ; Maisonneuve, B. ; Lemonnier, T. ; Deslys, J.P. ; Yates, F. ; Honegger, T. ; Rontard, J. ; Vigneron, P.A. (2025) Towards a quality control framework for cerebral cortical organoids. Scientific Reports. https://doi.org/10.1038/s41598-025-14425-x
Roudaut, M.; Caillaud, A.; Souguir, Z.; Bray, L.; Girardeau, A.; Rimbert, A.; Croyal, M.; Lambert, G.; Patitucci, M.; Delpouve, G.; Vandenhaute, E.; Le May, C.; Maubon, N.; Cariou, B.; Si-Tayeb, K. (2024). Human induced pluripotent stem cells-derived liver organoids grown on a Biomimesys® hyaluronic acid-based hydroscaffold as a new model for studying human lipoprotein metabolism. AIChE. https://doi.org/10.1002/btm2.10659
Pliner, L.; Laneret, N.; Roudaut, M.; Mogrovejo-Valdivia, A.; Vandenhaute, E.; Maubon, N.; Toillon, R.A.; Karrout, Y.; Treizebre, A.; Annicotte, J.S. (2024). Mechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic β-cell lines. Springer Nature. https://doi.org/10.1007/s44164-024-00078-z
- Messelmani, T. ; Le Goff, A. ; Soncin, F. ; Gilard, F. ; Souguir, Z. ; Maubon, N. ; Gakière, B. ; Legallais, C. ; Leclerc, E. ; Jellali, R. (2023). Investigation of the metabolomic crosstalk between liver sinusoidal endothelial cells and hepatocytes exposed to paracetamol using organ-on-chip technology. Science Direct. https://www.sciencedirect.com/science/article/pii/S0300483X23001361
- Parvatam, S., Pamies, D., Pistollato, F., Beken, S., Mariappan, I., Roth, A., ... & Coecke, S. (2023). Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2023.11.008
- Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568. https://doi.org/10.3390/ ijms241310568
- Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021. https://doi.org/10.29328/journal.apps.1001039
Cicero, J.; Trouvilliez, S.; Palma, M.; Ternier, G.; Decoster, L.; Happernegg, E.; Barois, N.; Van Outryve, A.; Dehouck, L.; Bourette, R.P.; Adriaenssens, E.; Lagadec, C.; Tarhan, C.M.; Collard, D.; Souguir, Z.; Vandenhaute, E.; Maubon, G.; Sipieter, F.; Borghi, N.; Shimizu, F.; Kanda, T.; Giacobini, P.; Gosselet, F.; Maubon, N.; Le Bourhis, X.; Van Seuningen, I.; Mysiorek, C.; Toillon, R.A. (2023). ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells. Springer Nature. https://doi.org/10.1186/s40164-023-00463-6
Messelmani, T.; Le Goff, A.; Soncin, F.; Souguir, Z.; Merlier, F.; Maubon, N.; Legallais, C.; Leclerc, E.; Jellali, R. (2023). Coculture model of a liver sinusoidal endothelial cell barrier and HepG2/C3a spheroids-on-chip in an advanced fluidic platform. Science Direct. https://www.sciencedirect.com/science/article/pii/S1389172323003249
- Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301. https://doi.org/10.3390/pharmaceutics14112301
- Maisonneuve, B. G. C., Libralesso, L., Miny, L., Batut, A., Rontard, J., Gleyzes, M., ... & Honegger, T. (2022). Deposition chamber technology as building blocks for a standardized brain-on-chip framework. Microsystems & Nanoengineering, 8(1), 86. https://doi.org/10.1038/s41378-022-00406-x
- Miny, L., Maisonneuve, B. G., Quadrio, I., & Honegger, T. (2022). Modeling neurodegenerative diseases using in vitro compartmentalized microfluidic devices. Frontiers in Bioengineering and Biotechnology, 10, 919646. https://doi.org/10.3389/fbioe.2022.919646
- Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67. https://doi.org/10.3390/cosmetics9040067
Messelmani, T.; Le Goff, A.; Souguir, Z.; Maes, V.; Roudaut, M.; Vandenhaute, E.; Maubon, N.; Legallais, C.; Leclerc, E.; Jellali, R. (2022). Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver’s Extracellular Matrix. MDPI. https://doi.org/10.3390/bioengineering9090443
- Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748, https://doi.org/10.3791/62748
- Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03. https://doi.org/10.1101/2021.03.05.434080
- Maisonneuve, B. G. C., Batut, A., Varela, C., Vieira, J., Gleyzes, M., Rontard, J., ... & Honegger, T. (2021). Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system. bioRxiv, 2021-03. https://doi.org/10.1101/2021.03.23.436675
De Conto, V.; Cheung, V.; Maubon, G.; Souguir, Z.; Maubon, N.; Vandenhaute, E.; Bérézowski, V. (2021). In vitro differentiation modifies the neurotoxic response of SH-SY5Y cells. Science Direct. https://www.sciencedirect.com/science/article/pii/S0887233321001600
Munoz-Garcia, J.; Jubelin, C.; Loussouarn, A.; Goumard, M.; Griscom, L.; Renodon-Cornière, A.; Heymann, M.F.; Heymann, D. (2021). In vitro three-dimensional cell cultures for bone sarcomas. Science Direct.
https://doi.org/10.1016/j.jbo.2021.100379- Fantuzzo, J., Robles, D., Mirabella, V., Hart, R., Pang, Z., Zahn, J. (2020). Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. Lab on a Chip, 2020-02. https://doi.org/10.1039/c9lc01179j
Vitali, E.; Boemi, I.; Tarantola, G.; Piccini, S.; Zerbi, A.; Veronesi, G.; Baldelli, R.; Mazziotti, G.; Smiroldo, V.; Lavezzi, E.; Spada, A.; Mantovani, G.; Lania, A.G. (2020). Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment. MDPI.
https://doi.org/10.3390/cancers12082143Belisario, D.C.; Akman, M.; Godel, M.; Campani, V.; Patrizio, M.P.; Scotti, L.; Hattinger, C.M.; De Rosa, G.; Donadelli, M.; Serra, M.; Kopecka, J.; Riganti, C. (2020). ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma. MDPI.
https://doi.org/10.3390/cells9030647Lane, R.; Simon, T.; Vintu, M.; Solkin, B.; Koch, B.; Stewart, N.; Benstead-Hume, G.; Pearl, F.M.G.; Critchley, G.; Stebbing, J.; Giamas, G. (2019). Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping. Nature Communications Biology.
https://doi.org/10.1038/s42003-019-0560-xSimon, T.; Pinioti, S.; Schellenberger, P.; Rajeeve, V.; Wendler, F.; Cutillas, P.R.; King, A.; Stebbing, J.; Giamas, G. (2018). Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma. Springer Nature.
https://doi.org/10.1186/s12943-018-0878-xSalaroglio, I.C.; Gazzano, E.; Abdullrahman, A.; Mungo, E.; Castella, B.; Abd-elrahman, G.E.F.A.; Massaia, M.; Donadelli, M.; Rubinstein, M.; Riganti, C.; Kopecka, J. (2018). Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. Springer Nature. https://doi.org/10.1186/s13046-018-0967-0
Salaroglio, I.C.; Panada, E.; Moiso, E.; Buondonno, I.; Provero, P.; Rubinstein, M.; Kopecka, J.; Riganti, C. (2017). PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy. Springer Nature. https://doi.org/10.1186/s12943-017-0657-0
- Honegger, T., Thielen, M. I., Feizi, S., Sanjana, N. E., & Voldman, J. (2016). Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks. Scientific reports, 6(1), 28384. https://doi.org/10.1038/srep28384
- Honegger, T., Scott, M. A., Yanik, M. F., & Voldman, J. (2013). Electrokinetic confinement of axonal growth for dynamically configurable neural networks. Lab on a Chip, 13(4), 589-598. https://doi.org/10.1039/C2LC41000A
Gomes, A.; Russo, A.; Vidal, G.; Demange, E.; Pannetier, P.; Souguir, Z.; Lagarde, J.M.; Ducommun, B.; Lobjois, V. (2016). Evaluation by quantitative image analysis of anticancer drug activity on multicellular spheroids grown in 3D matrices. Spandidos Publications.
https://doi.org/10.3892/ol.2016.5221Demange, E.; Kassim, Y.; Petit, C.; Buquet, C.; Dulong, V.; Le Cerf, D.; Buchonnet, G.; Vannier, J.P. (2012). Survival of cord blood haematopoietic stem cells in a hyaluronan hydrogel for ex vivo biomimicry. Journal of Tissue Engineering and Regenerative Medicine.
https://doi.org/10.1002/term.1482David, L.; Dulong, V.; Le Cerf, D.; Chauzy, C.; Norris, V.; Delpech, B.; Lamacz, M.; Vannier, J.P. (2004). Reticulated hyaluronan hydrogels: a model for examining cancer cell invasion in 3D. Science Direct.
https://doi.org/10.1016/j.matbio.2004.05.005
- [2025] F3OCI - Livre Blanc Organoïdes & Organes-sur-puce.
- [2025] Revvity - High-content imaging of brain-on-chip microfluidic devices using PreciScan intelligent acquisition.
- [2024] Characterizing sensory neurons as universal bio-digital sensors to explore PNS applications
- [2024] Traumatic Nerve Injury Platform
- [2023] Chemotherapy-Induced Peripheral Neuropathy-On-Chip Model : Utilizing the strength of compartmentalization
- [2023] Surface tension-based cell seeding in NETRI microfluidic devices
- [2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
- [2022] Synaptic transmission investigation using asymmetric shape microfluidic device DuaLink Shift
- [2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures
- [2022] Innovative microfluidic device for in vitro 3D cell culture
- [2022] Methodology for quantify cell viability after acute exposure of amyloid beta oligomers on human neurons
- [2021] High Thoughput microfluidic device for long-term culture and functional activity recording of organoids and explants
- [2021] Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
- [2021] Simple quantitative method of neurite length measurements in triangular microfluidic device
Devices
- NeuroFluidics™ MEA - DuaLink MEA
- NeuroFluidics™ MEA - DuaLink Shift MEA
- NeuroFluidics™ MEA - DuaLink Well MEA
- NeuroFluidics™ MEA - TriaLink MEA
- NeuroFluidics™ - DuaLink
- NeuroFluidics™ - DuaLink Ultra
- NeuroFluidics™ - DuaLink Shift
- NeuroFluidics™ - TriaLink
- NeuroFluidics™ - TriaLink Ultra
- MultiFluidics™ - Duplex
Cell Types
MPS World Summit 2025
- Coupling compartmentalized microfluidic platforms with MEA for advancing Neuromuscular junction modeling.
- Establishing a humanized in vitro model for pesticide-induced neurotoxicity: a collaborative effort between NETRI and ANSES.
- Development of a brain-organoid-on-chip platform for neurotoxicity testing.
Neurosciences 2024
- Advancing Neuromuscular Junction Modeling with Compartmentalized Microfluidic Platforms Coupled with MEA Functional Analysis
- Development of a Brain Organoid-on-Chip Platform for Neurotoxicity Testing
- Digital Signature Library: using neurons as universal bio-digital sensors
EUROoCS 2024
- Translational brain-on-a-chip models for Alzheimer's disease drug discovery
- Human Brain Organoid-on-Chip platform to improve organoid reproducibility and scalability for pharmaceutical studies
- Compartimentalized MEA Pain(s)-on-chip platform
MPS World Summit 2024
- Compartimentalized MEA Pain(s)-on-chip platform
- Human Brain Organoid-on-Chip platform to improve organoid reproducibility and scalability for pharmaceutical studies
- Translational brain-on-a-chip models for Alzheimer's disease drug discovery
AD/PD 2024
World of organoids 2024
- Prediction algorithm for neurotoxicity evaluation based on brain organoid-on-chip
- A new human brain organoid-on-chip model meeting biological and industrial requirements of neurological preclinical studies
SfN 2023
- Towards new relevant Alzheimer's disease models for target validation and drug testing
- A new human brain organoid-on-chip model meeting biological and industrial requirements of neurological precilinical studies
- Translational platforms of injury & pain-on-chip
- Automated organs-on-chip platform to reduce intra-laboratory cell culture variability
MPS World Summit 2023
- Automated Organs-on-chip platform to reduce intra-laboratory cell culture variability
- A new versatile 3D Organs-on-chip model allowing air-liquid interface, blood-tissue barrier recreation and multicompartment connection
- Functional skin-on-chip: a relevant in-vitro platform to replace animal models in drug and cosmetic development
- Translational model of nerve injury-on-chip
PNS 2023
NeuroFrance 2023
- Translational model of nerve injury-on-chip
- A new versatile 3D Organs-on-chip model allowing air-liquid interface, blood-tissue barrier recreation and multicompartment connection
SfN 2022
FENS 2022
- An Organ on chip platform to evaluate neuro immune signal transmission using human cells
- Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
- Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
EUROoCS 2022
- Deposition chamber technology as building blocks for a standardized brain on chip framework
- Development of an innervated skin-on-a-chip
- Human Brain-Organoids-on-ChipAdvanced microfluidic device for reproducible organoids culture
- Organs-on-Chip high throughput platform for pharmaceutical screening
- The DuaLink chips Improved fluidic isolation in microfluidic devices designed for neurons culture
MPS World Summit 2022
- Modeling the human Brain-on-Chip with human iPSC-derived Glutamatergic neurons
- Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injuryStandardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
- Human Brain-Organoids-on-Chip Advanced microfluidic device for reproducible organoids culture
SLAS Europe 2022
- Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
- Organs-on-Chip high throughput platform for pharmaceutical screening
Microphysiological Systems Workshop
SLAS International 2022
MPS World Summit 2021
- Deposition chamber technology as building blocks for a standardized brain-on-chip framework
- Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Neurosciences 2021
FSSCR 2021
- Microfluidic high-throughput screening platform to screen pre-clinical stage compound effects on neurite outgrowth of human Motor Neurons post-injury
- Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
MicroTas 2021
- Co-culture model of glutamatergic neurons and pediatric high-grade glioma cell lines in microfluidic devices to evaluate electrophysiological impact
- Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system.
EUROoCS 2021
- High throughput standardised microfluidic platform for internalization and axonal transport explorations of a preclinical neurological compound
- Co-culture model of glutamatergic neurons and pediatric high-grade glioma cell lines in microfluidic devices to evaluate electrophysiological impact
- Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system.
- Standardization criteria of hiPSC-derived neurons for Brain-on-Chip applications
Neurofrance 2021
- Co-culture model of glutamatergic neurons and pediatric high-grade glioma cell lines in microfluidic devices to evaluate electrophysiological impact
- High throughput standardised microfluidic platform for internalization and axonal transport explorations of a preclinical neurological compound
- Neurite growth kinetics regulation through hydrostatic pressure in a novel triangle-shaped neurofluidic system
ISSCR 2021
Devices
- NeuroFluidics™ MEA - DuaLink MEA
- NeuroFluidics™ MEA - DuaLink Shift MEA
- NeuroFluidics™ MEA - DuaLink Well MEA
- NeuroFluidics™ MEA - TriaLink MEA
- NeuroFluidics™ - DuaLink
- NeuroFluidics™ - DuaLink Ultra
- NeuroFluidics™ - DuaLink Shift
- NeuroFluidics™ - TriaLink
- NeuroFluidics™ - TriaLink Ultra
- MultiFluidics™ - Duplex
Cell Types - Co-culture
- Keratinocytes & Sensory Neurons
- Keratinoctes & Endothelial Cells
- Motor Neurons & Muscle Cells
- Glutamatergic Neurons & GABAergic Neurons
- Sensory Neurons, Astrocytes & DRG Cells
Cell Types - Culture
- NETRI - BioMIMESYS Liver (ECM)
- NETRI - BioMIMESYS Adipose Tissue (ECM)
- NETRI - BioMIMESYS Pancreas (ECM)
- NETRI - BioMIMESYS Oncology (ECM)
- NETRI - BioMIMESYS Brain (ECM)
- NETRI - BioMIMESYS Skin (ECM)
- Anatomic - Sensory Neurons
- Anatomic - Motor Neurons
- Axol Bioscience - Sensory Neurons
- Axol Bioscience - Motor Neurons
- Axol Bioscience - Muscle Cells
- FUJIFILM Cellular Dynamics - Glutamatergic Neurons
- FUJIFILM Cellular Dynamics - Motor Neurons
- BrainXell - GABAergic Neurons
- BrainXell - Glutamatergic Neurons
- bit.bio - Sensory Neurons
- bit.bio - Motor Neurons
- PromoCell - Keratinocytes
- Zen-Bio - Muscle Cells
Readouts
