NEURONS AS A SENSOR APPLICATIONS.
A SUITE OF TOOLS FOR A UNIQUE SELLING PROPOSITION.
NETRI transforms human neurons into predictive biological sensors, coupled with AI, called Neurons as a Sensor (NaaS), to create a new generation of quantifiable, industrializable preclinical models aligned with the regulatory transition to NAMs.
Neuron-as-a-Sensor (NaaS) is a carefully streamlined method for assessing novel compounds with early, enhanced predictivity. It is based on the realization that neurons are the natural bio-digital sensors of the body, and that their sensing capability can be harnessed universally using compartmentalized electrophysiology .
NaaS is an integrated platform combining proprietary microfluidic devices, hiPSC-derived cells or organoids, and advanced analytics software to generate predictive digital signatures using in preclinical development.
ESTABLISHING A NaaS PLATFORM.
INITIALIZATION.
Creation of NaaS biology platform and NaaS Model for a target application.
UPSCALING.
Build up of Digital NaaS model through Training Library of 100s of reference compounds.
SCREENING & DRUG DESIGN.
Transfer of methodology, devices and predictive model capabilities to client.
REGULATORY APPROVAL.
Extension of approved NaaS Model to multiple clients with CROs to handle volumes.
ONCOLOGY.
• Drug Induced Peripehral Neuropathy.
• Emetic & Nausea Response.
IMMUNOLOGY.
• Inflammatory Pain.
• Diabetic Peripheral Neuropathy.
DERMATOLOGY.
• Skin Model.
NEUROLOGICAL DISORDERS.
• Amyotrophic Lateral Sclerosis.
• Neurotoxicity Safety.
• Drug Induced Seizure.
NEUROTOXICITY.
• Neurotoxicity Chemical Safety.
