IMMUNOLOGY.
INFLAMMATORY PAIN.
Description.
Create a platform to capture the influence of immune cells (such as macrophages, mast cells, dendritic cells, and T cells…) on pain pathways and neuronal excitability by capturing interactions between immune cells and neurons.
Readouts.
• MEA recordings & Digital Signatures.
• ELISA.
• Imaging.
Advantages.
• Direct recording of neuronal reaction to immune cells.
• Provide predictive insights that drive safer, more effective drug development.
• Can be combined with various immune cells.
IMMUNOLOGY.
POTENTIAL APPLICATIONS.
• Diabetic Peripheral Neuropathy.
• Rheumatoid Arthritis: co-culture of hiPSC-derived sensory neurons and astrocytes to evaluate supernatant effect on the neuronal endings compartment.
OUR OFFERS.
Initialization.
Creation of NaaS biology platform and NaaS Model for a target application.
• In Your Lab: Develop your NaaS Model on your own terms.
• At NETRI: Let NETRI Develop your NaaS Model.
Upscaling.
Build up of Digital NaaS model through Training Library of 100s of reference compounds.
• Pre-Licensing: Test your molecules using your NaaS Model.
Screening & Drug Design.
Transfer of methodology, devices and predictive model capabilities to client.
• Licensing: Screen your molecules using an existing NaaS Model.
Regulatory Approval.
Extension of approved NaaS Model to multiple clients. Larger deals with CROs to handle volumes.
• Licensing & milestones.
