COMPARTMENTALIZED ELECTROPHYSIOLOGY.
INNERVATED SKIN.
KERATINOCYTES & hiPSC-DERIVED SENSORY NEURONS CO-CULTURE.
Description.
Create a platform to address sensitive skin or assess anti-itching compounds or on nerve endings with or without keratinocytes.
Readouts.
• MEA recordings.
• Mediators release dosage (ELISA).
• Imaging.
Advantages.
• Activate different pruritic pathways (activation of different receptors).
• Direct recording of nerve endings specifically.
• Ability to detect desensitization over time.
Potential Applications.
• Pruritus.
• Neuroinflammatory Skin Disorders.
• Cold Effect.
NEUROMUSCULAR JUNCTION.
MUSCLE CELLS & hiPSC-DERIVED MOTOR NEURONS CO-CULTURE.
Description.
Create compartmentalized NMJ with healthy / C9orf72 or patient derived motor neurons to assess compound efficacy to regain motor neuron and muscle function.
Readouts.
• Electrophysiological recordings of motor neurons.
• Muscle contraction.
• Imaging.
Advantages.
• Direct recording of ALS functional phenotype.
• Compatible with NaaS Approach.
Potential Applications.
• Amyotrophic Lateral Sclerosis.
• Botox-Like.
CNS CO-CULTURES.
hiPSC-DERIVED GLUTAMATERGIC & GABAERGIC NEURONS.
Description.
Create a Gluta-Gaba co-culture but only subject Gaba compartment to AβO to induce AD Phenotype. This allows to test compound’s efficacy against neurodegeneration with an internal reference.
Readouts.
• MEA recordings & Digital signatures.
• Imaging.
• Diagnosis.
Advantages.
• Direct recording of AD functional phenotype.
• Can evolve to be used as personalized medicine.
Potential Applications.
• Alzheimer’s Diseases.
CNS CO-CULTURES.
hiPSC-DERIVED GLUTAMATERGIC & DOPAMINERGIC NEURONS.
Description.
Create compartmentalized Dopaminergic / Glutamatergic co-culture and induce PD with misfolded protein oligomers. Assess compound efficacy against neurodegeneration.
Readouts.
• MEA recordings.
• Imaging.
Advantages.
• Direct recording of PD functional phenotype.
• Compatible with NaaS approach.
Potential Applications.
• Parkinson’s Disease.
CNS CO-CULTURES.
hiPSC-DERIVED GABAERGIC & STRIATAL NEURONS.
Description.
Create a Cortical towards HD-modified Striatal directional hiPSC co-culture, using μchannels with multiple electrodes per channel. This enables monitoring of dose-dependent transport velocity using Pridopidine.
Readouts.
• MEA recordings.
• Imaging.
Advantages.
• Direct recording of Compound effect on transport velocity.
• Compatible with NaaS approach.
Potential Applications.
• Huntington’s Disease.
OUR OFFERS.
Discovery Pack.
Familiarize yourself with NeoBentos MEA to initiate your compartmentalized electrophysiology model.
• 5 NeoBentos for 10 conditions and 8 replicates.
• UpLink Software.
• Online Training and 10 Hours of support meeting with our Field Application Scientist and/or scientists.
• Mono-culture SOP only (sensory neurons, motor neurons, keratinocytes, muscle etc...)
Development Pack.
Develop your own assay with NeoBentos MEA.
• Minimun 5 NeoBentos with volume discount (up to 35%).
• UpLink Cloud Software (secured cloud).
• On-site Training and 100 Hours of support meeting with our Field Application Scientist and/or scientists.
• All mono- and co-culture SOP (motor neurons, muscle, innervated skin, Gluta-GABA, etc...)
ARE YOU A PUBLIC RESEARCH LABORATORY?
At NETRI, academic research is a cornerstone of our mission. We firmly believe that major advances result from collaboration between public research laboratories and industry players. We offer products specially designed for academic teams to facilitate access to NAM industrial technologies.
