STANDARDIZED MPS APPLICATIONS.
INNERVATION.
THE ONLY COMPARTMENTALIZED ELECTROPHYSIOLOGY PLATFORM.
NETRI devices enable functional innervation of any cell types through its unique compartmentalized electrophysiology platform, NeoBento, designed to recreate physiologically relevant innervated in vitro models. By spatially isolating distinct cell populations while maintaining controlled connectivity through, the system allows precise modulation and recording of neuronal activity across compartments. This approach supports both 2D and 3D co-culture configurations, including complex models integrating innervation, vascularization, and multicellular environments. Combined with NETRI’s software UpLink+™, the platform enables high-content electrophysiological data extraction—capturing over 500 parameters from network dynamics—and translating them into actionable biological insights. This standardized framework provides standardized platforms to study functional connectivity, signal propagation, and compound-induced modulation in innervated human-relevant models.
INNERVATED SKIN.
KERATINOCYTES & hiPSC-DERIVED SENSORY NEURONS CO-CULTURE.
Description.
Create a platform to address sensitive skin or assess anti-itching compounds or on nerve endings with or without keratinocytes.
Readouts.
• MEA recordings.
• Mediators release dosage (ELISA).
• Imaging.
Advantages.
• Activate different pruritic pathways (activation of different receptors).
• Direct recording of nerve endings specifically.
• Ability to detect desensitization over time.
Potential Applications.
• Pruritus.
• Neuroinflammatory Skin Disorders.
• Cold Effect.
NEUROMUSCULAR JUNCTION.
MUSCLE CELLS & hiPSC-DERIVED MOTOR NEURONS CO-CULTURE.
Description.
Create compartmentalized NMJ with healthy / C9orf72 or patient derived motor neurons to assess compound efficacy to regain motor neuron and muscle function.
Readouts.
• Electrophysiological recordings of motor neurons.
• Muscle contraction.
• Imaging.
Advantages.
• Direct recording of ALS functional phenotype.
• Compatible with NaaS Approach.
Potential Applications.
• Amyotrophic Lateral Sclerosis.
• Botox-Like.
CNS CO-CULTURES.
hiPSC-DERIVED GLUTAMATERGIC & GABAERGIC NEURONS.
Description.
Create a Gluta-Gaba co-culture but only subject Gaba compartment to AβO to induce AD Phenotype. This allows to test compound’s efficacy against neurodegeneration with an internal reference.
Readouts.
• MEA recordings & Digital signatures.
• Imaging.
• Diagnosis.
Advantages.
• Direct recording of AD functional phenotype.
• Can evolve to be used as personalized medicine.
Potential Applications.
• Alzheimer’s Diseases.
CNS CO-CULTURES.
hiPSC-DERIVED GLUTAMATERGIC & DOPAMINERGIC NEURONS.
Description.
Create compartmentalized Dopaminergic / Glutamatergic co-culture and induce PD with misfolded protein oligomers. Assess compound efficacy against neurodegeneration.
Readouts.
• MEA recordings.
• Imaging.
Advantages.
• Direct recording of PD functional phenotype.
• Compatible with NaaS approach.
Potential Applications.
• Parkinson’s Disease.
CNS CO-CULTURES.
hiPSC-DERIVED GABAERGIC & STRIATAL NEURONS.
Description.
Create a Cortical towards HD-modified Striatal directional hiPSC co-culture, using μchannels with multiple electrodes per channel. This enables monitoring of dose-dependent transport velocity using Pridopidine.
Readouts.
• MEA recordings.
• Imaging.
Advantages.
• Direct recording of Compound effect on transport velocity.
• Compatible with NaaS approach.
Potential Applications.
• Huntington’s Disease.
ESTABLISHING A STANDARDIZED MICROPHYSIOLOGICAL SYSTEM.
NETRI help users to establish a biological model by providing devices, metrics extraction & analytics on-line software, full tech transfer (protocols of mono- or co-culture) and advice & couseling with scientific team (token based).
DISCOVERY PACK.
Establish the first proof of concept of biological model and familiarize with NoeBentos platform.
DEVELOPMENT PACK.
Develop your own assay with first proof of concept previously established.
STANDARD PACK.
Use your own standardized assay with a biological model previously established.
COMPARTMENTALIZED ELECTROPHYSIOLOGY.
ARE YOU A PUBLIC RESEARCH LABORATORY?
At NETRI, academic research is a cornerstone of our mission. We firmly believe that major advances result from collaboration between public research laboratories and industry players. We offer products specially designed for academic teams to facilitate access to NAM industrial technologies.
