THE WAY WE WORK.
Neuron-as-a-Sensor is a carefully streamlined method for assessing novel compounds with early, enhanced predictivity. It is based on the realization that neurons are the natural bio-digital sensors of the body, and that their sensing capability can be harnessed universally using compartmentalized electrophysiology .
Practicaly, NaaS is comprized of a suite of automated tools and protocols for experimentation, qualification, extraction, clustering and mapping of electrophysiological data using AI, paving the way for Digital Signature Libraries .
NaaS is a blueprint that can be deployed accross a variety of indications like Oncology, Vaccine Pain, Dermatology or Food & Safety Neurotoxicity.
THE WAY WE WORK.
Based on the Neurons as a sensor (NaaS) suite, we propose three different areas of collaboration to NETRI:
• Out-Licensing Programs for routine use of our patented technologies in your laboratories.
• Devices Sales for testing our patented technologies in your laboratories.
Out-Licensing Programs.
NETRI offers model-based licensing, including patents, devices, and databases. Clients pay setup fees for development, then license per application, benefiting from predictive data. These programs are composed of 3 steps :
1. Library Seeding: Co-development to establish a culture platform and seed library dedicated to your scientific and business needs.
2. Library Upscaling : Automation of target cell culture and blind screening of molecule panel, (fail clinical trial molecules, molecules on the market - to be defined with you …). Training of our AI and evaluation of predictability and translationality
3. Out-licensing: Technology transfer to your lab: training of technical team and support.. Definition of throughput, license perimeters and data ownership.
Buy Our Devices.
NETRI offers ready-to-use organs-on-chip devices, including starter kits and training, to accelerate your research.
• NeuroFluidics, to innervate 2D cell cultures with classic readouts (sequencing, dosing, imaging...).
• NeuroFluidics MEA, to innervate 2D and 3D cell cultures with classic readouts (sequencing, dosing, imaging...) and electrophysiological readouts (MEA).
• Uplink Software.
MAIN PIPELINE.
Oncology.
Explore pain management, efficacy and toxicity for oncology drug development with the Neurons as a Sensor (NaaS) suite.
• Chemotherapy-Induced Peripheral Neuropathy.
• Emetic Response.
• Efficacy testing of cancer therapeutics.
• Other Possibilities.
Immunology.
Explore inflammation as a central role in the regulation of neuronal signalling with NETRI’s immunology program.
• Inflammatory-mediated neuronal function.
• Evaluation of specific immune cell–neuron interactions.
• Other Possibilities.
Dermatology.
Test the effects of products on innervated skin or sensory neurons alone models.
• Atopic Dermatitis, Psoriasis, Skin irritation, Pruritus, Sensitization.
• Diabetes, Botox-like, Burn victim.
• Other Possibilities.
SECONDARY PIPELINE.
Neurological Disorders.
Model and/or diagnose neurodegenerative diseases with our brain-on-chip.
• Alzheimer's, Parkinson's, ALS, Dementia.
• Modeling & diagnosis.
• Other Possibilities.
Neurotoxicology.
Explore toxicology with the Neurons as a Sensor (NaaS) suite.
• Food & Chemical Safety.
• Pesticide screening.
• Pharma neurotoxicology.
