NeoBento™ HT Format
HT standard 96-well plate format
Lab equipments compatibilitiy
Up to 16 chips
NeoBento™ is the standard format for NeuroFluidics NETRI’s microfluidic chips, available up to 4 QuarterBentos™ (up to 16 chips).
By being in the standard ANSI format, this high-trhoughput format makes NETRI’s microfluidic devices as versatile and easy to handle as a typical 96-well plate without expansive equipments needed.
This format was designed to improve reproducibility and to be compatible with standard equipment (for liquid handling and imaging) and classic readouts (imaging and biochemical readouts).
In collaboration with Axion BioSystems , we have developed the NeoBento™ MEA.
NeoBento™ MEA is the standard format of the NeuroFluidics™ MEA line, available up to 4 QuarterBentos™ (up to 16 chips) and 672 electrodes.
In collaboration with Axion Biosystems we have developed MEA-capable high-throughput compartmentalized microfluidic devices in NeoBento HT format.
This partnership has allowed the creation of a line dedicated to electrophysiology, the NeuroFluidics MEA line and a utility software, UpLink, which runs locally with Axis.
The NeuroFluidics MEA line is composed of 3 products from 3 architectures that all use the same universal Axion MEA layer.
The NeuroFluidics MEA line is recognized by Axis Navigator, UpLink is our utility software to fetch relevant files from an active Axis session, process Axion Metrics and Network Metrics per microfluidic channel and generate an Excel file with the channel-specific metrics in a highly sortable format.
Microchannels recreate anatomical compartmentalization by allowing connection between channels. Due to their micrometric measurements (typically 3µm height and 5µm width), only neurites can grow within the microchannels, leaving the cell bodies within the compartments themselves. Depending on the desired results, the microchannels are available in 2 formats: tunnels and grooves.
Membrane technology consists of a solid matrix with defined holes or pores which have diameters ranging from less than 2 nm to more than 20 μm depending on the application (neuron extensions, molecules, proteins etc.). Generally used in cell biology for studying cell migration, cell-cell signaling and cell filtration, in NETRI’s microfluidic chips, they could be used for all these applications coupled with avantages of the microfluidic. Membrane mimic physiological barriers such as blood-brain-barrier
Depending on the application, one or two or all of our technologies can be combined in a single chip. The modular integration of our technologies allows the creation of multi-organ or multi-organoid architectures: