Up to 16 data points
3 compartments for independant culture per chips​
Microchannels technology to compartmentalize culture and connect channels

Each chips are compartmentalized by microchannels technology. This enables co-culture of different cell types (microbiota, neurons & intestinal cells…). Microchhanels technology also enables innervation by neuron endings (innervated gut…). By adding the MEA option, record the electrical activity of neurons to decode data from any innervated organ.

Products Details.


Specially designed to monitor the functional activity of 3 physiological compartments of cell populations.

16 microfluidic chips per NeoBento™ MEA PRO with 672 electrodes
8 microfluidic chips per NeoBento™ MEA EDGE with 336 electrodes
Cell type electrophysology activity isolation per compartment & remote stimulation


Specially designed to recreate different cellular microenvironment for co-culture of 3 different cell types with fluidic isolation.

16 microfluidic chips per NeoBento™ FULL
8 microfluidic chips per NeoBento™ LIGHT
Discontinuous connectivity


Specially designed to enhance axonal projection and recreate different cellular microenvironment for co-culture of 3 different cell types.

16 microfluidic chips per NeoBento™ FULL
8 microfluidic chips per NeoBento™ LIGHT
Continuous connectivity


High-Throughput Format

NeoBento™, the standard format for NeuroFluidics Devices chips, available up to 4 QuarterBentos™ (up to 16 chips).
Standard ANSI format (96-well plate)
Pump-free & expensive equipment-free
Standard equipment (liquid handling & imaging) compatibility


Compartmentalized microfluidics devices to co-culture 3 different cell types.
Each compartment has its own media & coating solutions
Discrimination of mode and mechanism of action
Pathophysiological applications

Readouts Compatibility

In-depth reading of the data to better understand the study results and potential implications.
Electrophysiological recording (MEA)
Imaging (Immunofluorescence, Calcium Imaging…)​
Biochimic analysis (ELISA, Lysis cells analysis, Liquid Chromatography…)​

Innervation of any Organ

Microchannels technology allow only the passage of neuron endings leaving cell bodies in compartment.
Microbiota-Gut-Brain Axis
Microbiota digital signature

Get Started Today.

NeuroFluidics MEA-recording Devices.

3 architectures : DuaLink MEA, DuaLink Shift MEA & TriaLink MEA
8 or 16 data points per plate
Training & Organs-on-chip Kits
Electrical neurons activity recording

NeuroFluidics Devices.

3 architectures : DuaLink, DuaLink Shift & TriaLink
8 or 16 data points per plate
Training & Organs-on-chip Kits
Imaging & Biochimic analyses readouts

Related Informations.

Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67.
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03.
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301.​
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568.
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021.
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748,
[2023] Chemotherapy-Induced Peripheral Neuropathy-On-Chip Model : Utilizing the strength of compartmentalization
[2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
[2023] Surface tension-based cell seeding in NETRI microfluidic devices
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures​
[2021] Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
TriaLink Protocol
TriaLink MEA Protocol
Fixation & Immunostaining Protocol
Recombinant adeno-associated virus Protocol
Neurological Disorders
PNS Disorders


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