UpLink.
Features.
• Utility Software
• Highly versatile document
• All MEA metrics
This is a highly versatile document that contains all MEA metrics tailored to the MEA NeuroFluidics Devices. The Raster Plots Tab allows to evaluate whole experiment at-a-glance, or access local dynamic HTML versions of each raster plot. The Metametrics tab contains all Axion BioSystems metrics parsed out per channel combination and chip, easily filterable and sortable. The Electrodes tab gives you the same versatility, at the individual electrode level.
Products Details.
UpLink.
UpLink supports all MEA metrics generated by Axion BioSystems that include basic and network metrics. Each metric is calculated for a variety of channel combinations.
• Mean Firing Rate (Hz)
• Number of Active Electrodes
• Burst Duration – Avg (s)
Benefits.
Highly versatile document
UpLink support all MEA metrics gereated by Axion BioSystems that include basic and network metrics.
• Average Metrics (Mean Firing Rate, Burst Duration…)
• Network Metrics (Synchrony Index, Network Burst Freq…)
• Basic Metrics
Software compatibility
Performance and user experience for analyzing the electrical activity of neurons.
• AxIS Navigator
• Windows 10 x64
• Excel to read compartmentalized report metrics
• Chome web browser recommended for reading raster plots
Recognized by Axis Navigator
The NeuroFluidics MEA layouts are recognized by Axis Navigator.
• Runs locally with AxIS
• Generation of channel-specific .spk files for use in NMT or standard Axion .csv files
Hardware compatibility
Stimulate (compound or electrical) one population to gauge the effect on the other
• DuaLink MEA
• DuaLink Shift MEA
• TriaLink MEA
• Master EDGE or PRO
Get Started Today.
NeuroFluidics Services.
• Technological Transfert
• FTE & Screening Services
• Co-development
• Analytical Services
NeuroFluidics Devices.
• 3 architectures with or without MEA-recording
• 8 or 16 data points per plate
• Training
• Organs-on-chip Kits
Related Informations.
• Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03. https://doi.org/10.1101/2021.03.05.434080
• Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301. https://doi.org/10.3390/pharmaceutics14112301
• Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568. https://doi.org/10.3390/ijms241310568
• Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021. https://doi.org/10.29328/journal.apps.1001039
• Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748, https://doi.org/10.3791/62748
• [2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
• [2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures
• DuaLink Protocol
• DuaLink MEA Protocol
• DuaLink Shift Protocol
• DuaLink Shift MEA Protocol
• TriaLink MEA Protocol
• Sensory Neurons Protocol
• Sensory Neurons MEA Protocol
• Fixation & Immunostaining Protocol
• Inflammatory Bowel Disease
• Alzheimer Disease
• PNS
• CNS
• DuaLink MEA
• TriaLink MEA
