Utility Software
Highly versatile document
All MEA metrics

This is a highly versatile document that contains all MEA metrics tailored to the MEA NeuroFluidics Devices. The Raster Plots Tab allows to evaluate whole experiment at-a-glance, or access local dynamic HTML versions of each raster plot. The Metametrics tab contains all Axion BioSystems metrics parsed out per channel combination and chip, easily filterable and sortable. The Electrodes tab gives you the same versatility, at the individual electrode level.

Products Details.


UpLink support all MEA metrics gereated by Axion BioSystems that include basic and network metrics. Each metric is calculated for a variety of channel combinations.

Mean Firing Rate (Hz)
Number of Active Electrodes
Burst Duration – Avg (s)


Highly versatile document

UpLink support all MEA metrics gereated by Axion BioSystems that include basic and network metrics.
Average Metrics (Mean Firing Rate, Burst Duration…)
Network Metrics (Synchrony Index, Network Burst Freq…)
Basic Metrics

Software compatibility

Performance and user experience for analyzing the electrical activity of neurons.
AxIS Navigator
Windows 10 x64
Excel to read compartmentalized report metrics
Chome web browser recommended for reading raster plots

Recognized by Axis Navigator​

The NeuroFluidics MEA layouts are recognized by Axis Navigator.
Runs locally with AxIS
Generation of channel-specific .spk files for use in NMT or standard Axion .csv files​

Hardware compatibility​

Stimulate (compound or electrical) one population to gauge the effect on the other
DuaLink MEA
DuaLink Shift MEA
TriaLink MEA
Master EDGE or PRO

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NeuroFluidics Services.

Technological Transfert
FTE & Screening Services
Analytical Services

NeuroFluidics Devices.

3 architectures with or without MEA-recording
​8 or 16 data points per plate
Organs-on-chip Kits

Related Informations.

Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67. https://doi.org/10.3390/cosmetics9040067
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03. https://doi.org/10.1101/2021.03.05.434080
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301. https://doi.org/10.3390/pharmaceutics14112301​
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568. https://doi.org/10.3390/ijms241310568
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021. https://doi.org/10.29328/journal.apps.1001039
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748, https://doi.org/10.3791/62748
[2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures​
DuaLink Protocol
DuaLink MEA Protocol
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DuaLink Shift MEA Protocol
TriaLink MEA Protocol
Sensory Neurons Protocol
Sensory Neurons MEA Protocol
Fixation & Immunostaining Protocol
Pediatric Glioblastoma
Inflammatory Bowel Disease
Alzheimer Disease
DuaLink MEA
DuaLink MEA
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