DuaLink, DuaLink MEA or DuaLink Shift NeuroFluidics Devices
Somas in one compartment
Extensions in one compartment
Microchannels technology to segregate mode of action of compound and isolate distal axons from soma and proximal axons

PNS Models enable the creation of an in vitro model mimicking human neuroanatomical architecture, for more relevant injury or treatment paradigms. By adding the MEA option, evaluate the functional impact of compound on neurons.

Products Details.

Directional Sensory Neurons Projections.

Culture of hiPSC-derived sensory neurons for Peripheral Nervous System applications.

DuaLink or DuaLink MEA for screening of drug candidate
DuaLink Shift for growth kinetics monitoring
Electrophysiology, Imaging and Biochimis analysis readouts

Directional Motor Neurons Projections.

Culture of hiPSC-derived motor neurons for Peripheral Nervous System applications.

DuaLink Shift for growth kinetics monitoring
Imaging and Biochimis analysis readouts
Injury & axonal regrowth after trauma model


High-throughput & interoperable solutions

NeoBento™, the standard format for NeuroPlatforms chips, available up to 4 QuarterBentos™ (up to 16 chips).
Standard ANSI format (96-well plate)
Pump-free & expensive equipment-free
Standard equipment (liquid handling & imaging) compatibility

Relevant in vitro model

Humanized in vitro PNS models for a wide variety of applications.
Human motor and sensory neurons models
Enhance axonal projections
Screening of potential drugs or therapeutic interventions for their effectiveness in preventing or treating therapies

Readouts compatibility​

In-depth reading of the data to better understand the study results and potential implications.
Electrophysiological recording (MEA)
Imaging (Immunofluorescence, Calcium Imaging…)
Biochimic analysis (ELISA, Lysis cells analysis, Liquid Chromatography…)

Compartmentalization & Fluidic isolation​

Compartmentalized microfluidics devices enabling injury or treatment paradigms aligned with real life situations.
Target only neurites and not cell bodies
Discrimination of mode of action and mechanism of neurotoxicity
Segregation of therapeutic modality: topical versus systemic

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NeuroFluidics Services.

Technological Transfert
FTE & Screening Services
Analytical Services

NeuroFluidics Devices.

3 architectures with or without MEA-recording
​8 or 16 data points per plate
Organs-on-chip Kits

Related Informations.

Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67.
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03.
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301.​
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568.
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021.
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748,
[2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures​
DuaLink Protocol
DuaLink MEA Protocol
DuaLink Shift Protocol
Sensory Neurons Protocol
Sensory Neurons MEA Protocol
Fixation & Immunostaining Protocol
Chemotherapy Induced Peripheral Neuropathy
Nerve Injury
DuaLink MEA
DuaLink Shift


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