DuaLink or Duplex Well NeuroFluidics Devices
Primary keratinocytes in one compartment
hiPSC Sensory Neurons or endothelial cells in one compartment
Microchannels technology to connect keratinocytes by endings sensory neurons
Membrane technology to perfuse keratinocytes by endothelial cells

Skin Models enables the creation of an in vitro innervated or irrigated skin model. By adding the MEA option, evaluate the functional impact of ingredient or product on neurons.

Products Details.

Innervated Skin.

Co-culture of primary keratinocytes and hiPSC-derived sensory neurons.

DuaLink or DuaLink MEA
Electrophysiology, Imaging and Biochimis analysis readouts
Fully human in vitro model

Irrigated Skin.

Co-culture of primary keratinocytes and endothelial cells.

Duplex Well
Imaging and Biochimis analysis readouts
Fully human in vitro model


Cosmetic Regulation

Cosmetic regulation ensures product safety, labeling accuracy, and adherence to quality standards in the beauty industry.
No animal testing
Drug and cosmetic efficacy and toxicity
Compatible with standard analytical method and tools


Compartmentalized microfluidics devices to recreate skin compartment and neurons or endothelial cells compartment.​
Discrimination of mode and mechanism of action
Pathophysiological applications (sensitive skin and pruritus, inflammatory dermatosis…)

Fully Compatible​

NeoBento™, the standard SBS format for NeuroPlatforms for readouts and lab equipments compatibility.
Pump-free & expensive equipment-free
Standard equipment compatibility
Electrophysiology, imaging and biochimic analysis readouts compatibility

PDMS Optically Transparent​

Soft silicon material, optically transparent for microscopy compatiblity and porous gas permability.
Imaging (Immunofluorescence, Calcium Imaging…)
Confocal Imaging
Perfusion-free with high biocompatibility

Get Started Today.

NeuroFluidics Services.

Technological Transfert
FTE & Screening Services
Analytical Services

NeuroFluidics Devices.

3 architectures with or without MEA-recording
​8 or 16 data points per plate
Organs-on-chip Kits

Related Informations.

Guichard, A., Remoué, N., & Honegger, T. (2022). In vitro sensitive skin models: review of the standard methods and introduction to a new disruptive technology. Cosmetics, 9(4), 67.
Maisonneuve, B. G. C., Vieira, J., Larramendy, F., & Honegger, T. (2021). Microchannel patterning strategies for in vitro structural connectivity modulation of neural networks. BioRxiv, 2021-03.
Castiglione, H., Vigneron, P. A., Baquerre, C., Yates, F., Rontard, J., & Honegger, T. (2022). Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications. Pharmaceutics, 14(11), 2301.​
Gabriel-Segard, T.; Rontard, J.; Miny, L.; Dubuisson, L.; Batut, A.; Debis, D.; Gleyzes, M.; François, F.; Larramendy, F.; Soriano, A.; et al. (2023). Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases. Int. J. Mol. Sci., 24, 10568.
Rontard J, Maisonneuve BGC, Honegger T. (2023). Expanding human-based predictive models capabilities using organs-on-chip: A standardized framework to transfer and co-culture human iPSCs into microfluidic devices. Arch Pharm Pharma Sci. ; 7: 017-021.
Fuchs, Q., Batut, A., Gleyzes, M., Rontard, J., Miny, L., Libralato, M., Vieira, J., Debis, D., Larramendy, F., Honegger, T., Messe, M., Pierrevelcin, M., Lhermitte, B., Dontenwill, M., Entz-Werlé, N. (2021). Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions. J. Vis. Exp. (177), e62748,
[2023] Compartimentalized culture of primary or hiPSC-derived neurons using an MEA-capable high-throughput organs-on-chip platform
[2022] The DuaLink Chips how to improve reproducibility in compartmentalized co-cultures​
[2021] Evaluation of amyloid beta oligomers (AβO) effects on functional network integrity of rodent hippocampal neurons
DuaLink Protocol
DuaLink MEA Protocol
Sensory Neurons Protocol
Sensory Neurons MEA Protocol
Fixation & Immunostaining Protocol
Innervated Epidermis
DuaLink MEA


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