Biological Models
• Pain & Injury
• Skin
• Neurological Disorders
In our lab.
Our R&D Remote Services provide predictive datas on toxicity, efficacy and modes of action in discovery & pre-clinical phases.
Biological Models.
Pain & Injury
Skin
Neurological Disorders
Pain & Injury
Applications:
• Chemotherapy Induced Peripheral Neuropathy
• Sensory neurons responses
• Motor Neurons Nerve Injury
Biological features:
• Compartmentalization to apply compound only on somas or neuron endings
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics from AxIS Navigator
• Specific architecture for monitoring neurite regrowth after trauma (chemical or mechanical)
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
• Chemotherapy Induced Peripheral Neuropathy
• Sensory neurons responses
• Motor Neurons Nerve Injury
Biological features:
• Compartmentalization to apply compound only on somas or neuron endings
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics from AxIS Navigator
• Specific architecture for monitoring neurite regrowth after trauma (chemical or mechanical)
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
Skin
Applications:
• Innervated Skin 2D
• Sensory Neurons Nerve Injury
Biological features:
• Compartmentalization to co-culture 2 different cell types
• Compartmentalization to apply compound only on somas or neuron endings or non-neuronal cells
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics from AxIS Navigator
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
• Innervated Skin 2D
• Sensory Neurons Nerve Injury
Biological features:
• Compartmentalization to co-culture 2 different cell types
• Compartmentalization to apply compound only on somas or neuron endings or non-neuronal cells
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics from AxIS Navigator
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
Neurological Disorders
Applications:
• Co-culture of glutamatergic & GABAergic neurons (hiPSCs)
• Co-culture of rodent cortical-hippocampal neurons
• Barin organoid
Biological features:
• Compartmentalization to co-culture 2 neuronal cell types
• Compartmentalization to apply compound only on somas or neuron endings
• Synaptic isolation in one compartment
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics
• Specific architecture for growing and maintaining organoids
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
• Co-culture of glutamatergic & GABAergic neurons (hiPSCs)
• Co-culture of rodent cortical-hippocampal neurons
• Barin organoid
Biological features:
• Compartmentalization to co-culture 2 neuronal cell types
• Compartmentalization to apply compound only on somas or neuron endings
• Synaptic isolation in one compartment
• MEA capability to record the functional effect of the compound only on somas or neuron endings
• Own utility software, UpLink, to output and process all MEA metrics
• Specific architecture for growing and maintaining organoids
• SBS format for use in automated high-throughput screening (in-house automation)
• Industrial capacity for high throughput, NeuroFluidics™ Line
Readouts, please refer to this page for the entire list.
• Imaging (Immunofluorescence, Calcium imaging…)
• Biochimic analysis (ELISA, Supernatant analysis…)
• Electrophysiology (Axion MEA metrics, Compartmentalized Raster Plots…)
How does it work?
Overview
Concrete examples: CIPN-MEA model
Resources
Overview
Translate your data into usable results and define toxicity, efficacy and mode of action of your compound with our R&D department. We have built up in-depth expertise through scientific projects in the fields of neuroscience and dermocosmetics (pain, neurological disorders, sensitive skin…).
① Kick-off meeting:
• Define the global scope of project
② Definition of the model:
• Select the cell(s) (Sensory neurons, GABAergic neurons, keratinocytes, endothelial cells, etc…)
• Select the readout(s) (Immunofluorescence, ELISA, electrophysiology, etc…)
• Select the architecture(s) (NeuroFluidics™ line, NeuroFluidics™ MEA line, etc…)
• The global scope of the work & budget
③ Begin experiment:
• Reference molecules
• Vehicule
• Molecule of interest
④ Deliverables:
• Raw datas
• Comprehensible reports
① Kick-off meeting:
• Define the global scope of project
② Definition of the model:
• Select the cell(s) (Sensory neurons, GABAergic neurons, keratinocytes, endothelial cells, etc…)
• Select the readout(s) (Immunofluorescence, ELISA, electrophysiology, etc…)
• Select the architecture(s) (NeuroFluidics™ line, NeuroFluidics™ MEA line, etc…)
• The global scope of the work & budget
③ Begin experiment:
• Reference molecules
• Vehicule
• Molecule of interest
④ Deliverables:
• Raw datas
• Comprehensible reports
Concrete examples: CIPN-MEA model
A concrete example with our Chemotherapy-Induced Peripheral Neuropathy (CIPN) model: CIPN-on-chip.
① Kick-off meeting:
• Define the global scope of project
② Definition of the model:
• Sensory neurons
• Immunofluorescence, % surface covered by axons in channel 3, number of blebs in channel 3 and electrophysiology recording
• DuaLink MEA from NeuroFluidics™ MEA line
• The global scope of the work & budget: 6 months with 2 workpackages
③ Begin experiment:
• Reference molecules Paclitaxel (PIPN model) and Oxaliplatin (OIPN model)
• Vehicule
• Molecule of interest: time-dose response on PIPN and OIPN models
④ Deliverables:
• Raw datas
• Comprehensible reports
① Kick-off meeting:
• Define the global scope of project
② Definition of the model:
• Sensory neurons
• Immunofluorescence, % surface covered by axons in channel 3, number of blebs in channel 3 and electrophysiology recording
• DuaLink MEA from NeuroFluidics™ MEA line
• The global scope of the work & budget: 6 months with 2 workpackages
③ Begin experiment:
• Reference molecules Paclitaxel (PIPN model) and Oxaliplatin (OIPN model)
• Vehicule
• Molecule of interest: time-dose response on PIPN and OIPN models
④ Deliverables:
• Raw datas
• Comprehensible reports
Resources
